A one year followup of chronic arthritis following rubella and hepatitis B vaccination

[Sheri Nakken]

http://www.ncbi.nlm.nih.gov/entrez/quer ... ed&list_ui
ds=12508767&dopt=Abstract

1: Clin Exp Rheumatol. 2002 Nov-Dec;20(6):767-71. Links
A one year followup of chronic arthritis following rubella and
hepatitis B vaccination based upon analysis of the Vaccine Adverse Events
Reporting System (VAERS) database.

* Geier DA,
* Geier MR.

MedCon, Inc., Silver Spring, Maryland, USA. mgeier@erols.com

OBJECTIVES: This analysis examined the incidence rate of chronic
arthritis adverse reactions reported following adult rubella and hepatitis
B vaccinations. In this analysis, etiologic mechanisms for chronic
arthritis following adult rubella and hepatitis B vaccines were also
explored. METHODS: The Vaccine Adverse Events Reporting System (VAERS)
database was analyzed for the incidence rate of reported cases of chronic
arthritis in comparison to Tetanus-diphtheria (Td) and tetanus toxoid adult
vaccine control groups. RESULTS: Chronic arthritis adverse reactions
following adult rubella vaccination were primarily reported in females
(female/male ratio = 3.0), at about 45 years-old, and at a mean onset time
of 10-11 days following vaccination. Chronic arthritis adverse reactions
following adult hepatitis B vaccination were also primarily reported in
females(female/male ratio = 3.5), at about 33 years-old, and with a mean
onset time of 16 days following vaccination. The incidence rates of chronic
arthritis following adult rubella and adult hepatitis B vaccinations were
statistically significantly increased, by chi 2 analysis, in comparison to
the adult vaccine control groups. The attributable risk of chronic
arthritis following adult rubella vaccine ranged from 32 to 53 and from 5.1
to 9.0 following adult hepatitis B vaccine in comparison to the adult
vaccine control groups. CONCLUSION: This study revealed that adult rubella
and adult hepatitis B vaccines were statistically associated with chronic
arthritis which persisted for at least one year. The etiology for these
adverse reactions may involve autoimmune mechanisms. Furthermore, potential
biases in the reporting rates of adverse reactions to VAERS were not observed.

PMID: 12508767 [PubMed - indexed for MEDLINE]

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