Cannabinoid system and neuroinflammation: implications for multiple sclerosis

[Jeff]

There are many beneficial effects that can be gotten with homeopathic cannabis products this may help you in directing some of your patients. This is just for information, this is why I was just asking information before.
Cannabinoid system and neuroinflammation: implications for multiple sclerosis"

Neuroimmunomodulation. 2007;14(3-4):182-7. Epub 2007 Dec 5.
Cannabinoid system and neuroinflammation:

implications for multiple sclerosis
There is a growing amount of evidence suggesting that cannabinoids may be neuroprotective in central nervous system inflammatory conditions.
Advances in the understanding of the physiology and pharmacology of the cannabinoid system have potentiated the interest in cannabinoids as potential therapeutic targets. Here our aim was to update the actions of cannabinoids on immune system and glial cells and their implications on multiple sclerosis. We also show our results on the modulation of cytokines of the IL-12 family by cannabinoids in macrophages and brain microglia.

We used murine primary cultures of macrophage and microglia activated by lipopolysaccharide/IFN-gamma and Theiler's virus to study the effects of cannabinoids on the regulation of IL-12 and IL-23 mRNA and protein IL-12p40, evaluated by RT-PCR and ELISA, respectively. Cannabinoids negatively regulate the production of these cytokines by microglial cells in part due to the activation of CB(2) receptors.

The effects of cannabinoids on cytokine brain work and on the regulation of neuroinflammatory processes may affect chronic inflammatory demyelinating diseases such as multiple sclerosis.

Copyright (c) 2007 S. Karger AG, Basel.PMID: 18073512 [PubMed - in process]
No information in this letter should be construed as medical advice.
This information is for educational purposes only.

Jeff Frankel
10360 Pine Lakes Blvd
North Fort Myers, Fl 33903
239-731-2655
http://www.msprotocols.com/
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