Happy New year for all,
I have a patient who has been taking melatonin for 1 year. Does anyone have experience with discontinuing it? Has one to be as careful as with corticoids?
MArco
Dr. M. Franzreb Corbelletti
Castellana 171 Bajo izda., 28046 Madrid
www.drmarcofranzreb.com
Tel.: 914491957
Fax: 914491965
OT melatonin
Re: OT melatonin
Hi Marco,
Others may have experience with melatonin but here is information I
found in 'Hyperhealth' about study into the effect of Melatonin:
·
"A physiological dose of melatonin (0.5 mg) or placebo was given at
bedtime to night shift workers (n = 21) for seven days, and
endogenous melatonin profiles were measured on the eighth day. The
amplitude of endogenous melatonin secretion was unchanged by
treatment. Also, a melatonin treatment trial using a 50 mg daily
bedtime dose for 37 days to a blind subject resulted in no change in
the endogenous melatonin profile. Circulating melatonin can shift
the phase, but does not alter the amplitude, of pineal melatonin
secretion." Quoted from Matsumoto, M., et al. 'The amplitude of
endogenous melatonin production is not affected by melatonin
treatment in humans.' Journal of Pineal Research. 22(1):42-44, 1997.
and also in Hyperhealth:
"Toxicity studies conducted on humans using Melatonin in dosages
ranging from 300 mg per day for 9 months up to 1,000 mg per day for 6
months have produced no toxicity or adverse reactions other than
daytime Drowsiness and daytime Fatigue."
There also doesn't seem to be an issue with missing doses or taking
it sporadically. In fact the information suggested that it is better
to skip a dose if you're purposely having a late night because
otherwise it upsets your circadian rhythm.
I'm guessing what you would be managing as it is withdrawn would just
be the underlying disease being allowed to express itself and the
patient's willingness to tolerate their disease symptoms.
Gail.
--- In minutus@yahoogroups.com, marco franzreb
wrote:
anyone have experience with discontinuing it? Has one to be as
careful as with corticoids?
Others may have experience with melatonin but here is information I
found in 'Hyperhealth' about study into the effect of Melatonin:
·
"A physiological dose of melatonin (0.5 mg) or placebo was given at
bedtime to night shift workers (n = 21) for seven days, and
endogenous melatonin profiles were measured on the eighth day. The
amplitude of endogenous melatonin secretion was unchanged by
treatment. Also, a melatonin treatment trial using a 50 mg daily
bedtime dose for 37 days to a blind subject resulted in no change in
the endogenous melatonin profile. Circulating melatonin can shift
the phase, but does not alter the amplitude, of pineal melatonin
secretion." Quoted from Matsumoto, M., et al. 'The amplitude of
endogenous melatonin production is not affected by melatonin
treatment in humans.' Journal of Pineal Research. 22(1):42-44, 1997.
and also in Hyperhealth:
"Toxicity studies conducted on humans using Melatonin in dosages
ranging from 300 mg per day for 9 months up to 1,000 mg per day for 6
months have produced no toxicity or adverse reactions other than
daytime Drowsiness and daytime Fatigue."
There also doesn't seem to be an issue with missing doses or taking
it sporadically. In fact the information suggested that it is better
to skip a dose if you're purposely having a late night because
otherwise it upsets your circadian rhythm.
I'm guessing what you would be managing as it is withdrawn would just
be the underlying disease being allowed to express itself and the
patient's willingness to tolerate their disease symptoms.
Gail.
--- In minutus@yahoogroups.com, marco franzreb
wrote:
anyone have experience with discontinuing it? Has one to be as
careful as with corticoids?