Genetics and Homeopathy

[Ellen Madono]

helpful for the uninformed. https://en.wikipedia.org/wiki/Epigenetics

Ellen Madono
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[Irene de Villiers]

My pleasure:-)
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[Diane]

Irene,
Thanks for the understandable explanation regarding acetylation and methylation of epigenes and a correlation between methylation and severe circumstances. Gosh, but that explains a lot to me, personally.
For a person that has experienced early and long-term mental, emotional, physical and sexual abuse in childhood and early adult hood, and that is deeply plagued by PTSD to the degree they cannot function in society, lives in deep isolation and whose body is unable to produce enough of its own energy to more than breath, shower occasionally, eat occasionally and be in constant survival mode, what in heaven's name are they to do to find/get help in reversing this situation?!
There are no words for the degree of frustration and desperation, for an entire life totally un-lived.
D
My pleasure:-)
________________________________
--
Irene de Villiers, B.Sc AASCA MCSSA D.I.Hom/D.Vet.Hom.
P.O. Box 4703 Spokane WA 99220.
www.Furryboots.info
(Info on Feline health, genetics, nutrition & homeopathy)
"Man who say it cannot be done should not interrupt one doing it."

[healthinfo6]

Basically, if I understood it well, methylation/epigenetics is transmissible intergenerationally....here is the question: is this a fixed situation or can that be reversed in the further generations? or simply controlled?

Dr. Joe,

My blood testing showed neither over or under methylation, part or all as measured by homocysteine, but I have severe pyrrole disorder based on urine test, now helped my large doses of Zinc Picolinate, B6, P5P and Black Currant Seed oil. Borage oil is the recommended one.
Mine is inherited, from my father and currently appears to be Tubercular as taking TubK LMs seems to occasionally lessen need for the supplements but still experimenting. While I was early identified in the 1970s before much was known, it became severe during middle age along with other miasmatic progressing conditions, like diabetes.
"The good news is that the gene regulation abnormalities from deviant marks appear to be reversible, suggesting a potential cure for epigenetic disorders. I can imagine a future in which newborns are scanned for deviant bookmarks, followed by treatment to normalize these chemical tags. This could eliminate the predispositions for cancer, heart disease and mental disorders that have plagued society for centuries."

"Although the technology for reversing deviant bookmarks is still unavailable, effective therapies for treatment of many epigenetic disorders are known today. For example, many paranoid schizophrenics exhibit excessive dopamine activity that can be normalized by Vitamin B-3 that uncoils DNA to increase gene expression of DAT proteins. In another example, methionine and SAMe act as serotonin reuptake inhibitors by compacting chromatin to reduce production of SERT transport proteins. We don’t yet know how to reverse deviant marks, but epigenetic science is guiding the development of therapies that uncoil or compact DNA to counter abnormal gene expression. It appears that nutrients and other natural substances are especially promising for dealing with epigenetic disorders. I believe the need for psychiatric medications will gradually fade away as science advances."

http://www.walshinstitute.org/epigenetics.html

The next USA training for MDs, DOs and other licensed CAMs.

http://www.walshinstitute.org/practitio ... ation.html
I was a patient case in the previous spring training, evaluated by Dr. Walsh and interviewed by the class, there to learn how to use nutrients to treat these epigenetic and genetic conditions vs. drugs.
You can have your family tested in New Zealand for possible pyrrole disorder
http://www.pharmaceutical.co.nz/kryptopyrroles/
The nutritional treatment for methylation issues appears independent of the specific gene causing it and there can be many,
MHTFR variant issues are more common and easily tested for and listed along with FKBP5 in this table.
http://www.nature.com/nrg/journal/v9/n7 ... 81_T2.html
Interestingly, the FKBP5 gene can be affected by all types of traumatic stress like child abuse.
Likely one's constitution/core/ICT determines how much stress one can endure before affecting this gene.
"Also, variants within the FKBP5 gene have been shown to modulate the risk of developing MDD in relation to stressful experiences (92 ). For example, Appel et al. (40 ) reported a significant gene × environment interaction by investigating the effect of a functional SNP within FKBP5 gene (rs1360780) on depression development in more than 2,000 German people. In particular, they found that TT subjects with a history of physical abuse had an enhanced risk for depression development when compared to CC/CT individuals. This interaction between the rs1360780 and traumatic life events in predicting the onset of MDD was confirmed by another study performed in 884 adolescent and young adult individuals characterized for traumatic life events (UK environmental risk longitudinal twin study) (41 ). Subsequently, the same SNPs within the FKBP5 gene have been associated also with peritraumatic dissociation among injured children (93 ), with recovery from psychosocial stress in normal controls (45 ), and also with the association between childhood abuse and the development of post-traumatic stress disorder (46 ). Another evidence that supports the role of FKBP5 as mediator of stress exposure comes from a study where a particular FKBP5 haplotype of four SNPs (rs3800373, rs9296158, rs1360780, rs9470080) was found associated with an increased risk of suicide attempts but only in individuals with a history of childhood trauma (94 ).
These results, taken together, strongly support a role of the FKBP5 gene in the pathogenesis of stress-related depression, likely mediated through the influence of individual level of GR resistance and, consequently, glucocorticoid signaling."
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424810/
Methylation Problems Lead to 100s of Diseases

http://suzycohen.com/articles/methylation-problems/
Oddly, methylation issues are recognized by mainstream conventional allopathy with medical diagnosis coding but pyroluria aka pyrrole disorder or kryptopyrrole is not while both have lab tests to diagnose and both are treated nutritionally. There is no Big Pharma necessary for pyroluria as vitamins, minerals correct and don't know if any drugs exist for methylation issues.
I know two brothers whose mother was in Auschwitz and her family was exterminated and she was sole survivor.
She always seemed emotionally strong constitutionally with a pleasant refined manner at times tough with attitude.
A heavy smoker, she couldn't care less if she blew smoke in your face, would light up in a car, dining no matter how much one complained.
Now wondering if that war stress and trauma caused an FKBP5 issue that may have affected her sons as both are much weaker emotionally.
Thanks for bringing up this lesser known but important gene variation.
Susan

[Dr. Joe Rozencwajg, NMD]

Thanks.

I will check your link for NZ!

Joe.

Dr. J. Rozencwajg, NMD.

"The greatest enemy of any science is a closed mind"

www.naturamedica.co.nz

[Ellen Madono]

Wow, how do you check such a link?

Ellen Madono

[Dr. Joe Rozencwajg, NMD]

This one, in the text: http://www.pharmaceutical.co.nz/kryptopyrroles/
Dr. J. Rozencwajg, NMD.

"The greatest enemy of any science is a closed mind"

www.naturamedica.co.nz

[Dr. Joe Rozencwajg, NMD]

This thread has kind of died but I just received another paper, showing the "miasmatic" effect of environment through multiple generations without DNA modification.
1. Keith Siklenka, Serap Erkek, Maren Godmann, Romain Lambrot, Serge McGraw, Christine Lafleur, Tamara Cohen, Jianguo Xia, Matthew Suderman, Michael Hallett, Jacquetta Trasler, Antoine H. F. M. Peters, and Sarah Kimmins. Disruption of histone methylation in developing sperm impairs offspring health transgenerationally. Science, 8 October 2015 DOI: 10.1126/science.aab2006
Now we can almost definitely say that the Core (formerly "constitution") can be changed by external factors and that it is transmissible, either through integration into the DNA or through external effects....as usual, Hahnemann was right...

Joe

--
Dr. J. Rozencwajg, NMD.

"The greatest enemy of any science is a closed mind"

www.naturamedica.co.nz

[Ellen Madono]

Hi,
What about all the research on use of hormones affecting even the 3rd generation? That was probably discussed.
Ellen

Ellen Madono

[Irene de Villiers]

I think the important part is "WITHOUT modification of DNA".

DNA is part of the innate constitutioal type (ICT) of every individual of every species.
The ICT types do not just apply to humans. They apply equally - and in the SAME ways - to animals.
The word "constitution" is important to retain as it has the correct meaning, that of the CONSTITUENTS of the individual, the things that make up that individual, or the ingredients of the individual that WILL be there - PREDICTABLE - as part of their basic makeup - ALWAYS.

Diseases are not predictable or always there, ansd th ey vary by species, unlike ICT types.
Diseases are not therefore a constituent of any ICT.

The constituents of an ICT are a well defined set, and that set applies to all people and all animals of all species with that particular set of inherited features.

A disease is NOT a feature of an individual or of a type or category of individual ... inherited or otherwise.
A disease is merely a mistunement that is potentially possible for the individual, wheras ICT features are ALWAYS there in ALL members of that ICT in ALL species.

It is a mistake to graft any disease onto a constitutional type, regardless what kind of disease it is, acute, chronic or miasm.
To do so would be trying to make that disease an integral component of ALL members of that type, whatever species they belong to. That literally is NOT the case and can not be the case. It is an impossibility. .
The diseaes and miasms of different species are NOT the same - that alone precludes putting miasms into a ICT or core type.
No disease is automatically a part of the costitutioal makep of any idividual of any species.
No individual will automatically get ANY disease to wich s ICT may be predisposed.

Diseases are only POTENTIAL mistunements for an ICT type, not things that WILL occur = not features always present - thus NOT constitutional or ICT or Core features.
Those innate features need to apply to ALL members - in ALL species, who share the ICT.

At least Three categories of diseases are possible:
Acute, chronic, and miasm. (Add poisonings, injuries, nutritional errors, physical and mental damage, etc)
Each has specific mechanisms by which an individual acquires the illness or damage - it is all damage of some kind - and each has specific mechanisms by which an individual gets rid of the disease/damage.
BUT in all cases, the disease is a potential temporary visitor to mistune the basic or core or ICT type.

The diseases that can do this vary by species.
ANd they will continune to vary as man invents new ways to cause damage/illness.
But while those can vary, the ICT can not vary - not in any species. It is a fixed set of traits that is ALWAYS inherited by that ICT.

A disease such as a miasm, or any disease, is NOT always inherited by that ICT, so it cannot be PART of the set list of inherited traits which is fixed for the ICT.
We know now that miasms are aquired diseases that affect epigene switches, and are passed on to offspring, NOT in the genes, not in ther DNA but only as a part of tissue damage to do with access to a gene, and which has yet to be fixed.
Diseases are by definition things that went wrong that have yet to be fixed. Things that go wrong are NOT part of an ICT, they are possible (not definite) events that COULD happen to an ICT - of any species.

That some are stuck in place from one generation to another, does not change that principle.
The ICT or core individual EXCLUDES diseases, and is the definition of the combined inherited traits that ALL members of the ICT of ALL species, do inherit.
They can inherit PREDISPOSITIONS - not diseases.
SO a predisposition to a disease (acute, chronic or miasm) can be included in an ICT's characteristics, but never an actual disease. Actual diseases are not inherited. Mechanisms (caused by damage of some kind) to cause illness can be inherited, not the disease result.

Even when a miasm switch is in an unwanted position - it is a predisposition - NOT a disease.
The disease is what occurs when that switch allows a response of bad protein manufacture.
The switch positions of all the epigenes WILL be passed down as pre-set predispositions - beneficial or otherwise - but not as diseases.

Joe writes:
This is just another example of how epigene switch positions are passed to offspring in whatever position they happen to be when sperm are made.
There is NO effect on the DNA.
NO disease is passed down.
Only the epigene switch position is passed down - the predisposition to a specific use of a specific gene.
NO we can not say that.
There is no change of the basic makeup or constitution of the individual.
A dsease predispostion - damage to the individual and not a core type/ICT change - was set up during their lifetime and that will be passed to offspring.
It is not a change of the basic constitution or innate constitutional type.
It is just that BY CHANCE this individual got a miasm disease (caused by damage to them), but that is not PART of them, it is merely damage that needs to be addressed.
Nothing is transmitted.
Damage is there when caused, till it is fixed.
"Transmitted" implies a mechanism to pass down a trait, and there is none.
The damage done to the epigene layer merely remains in the epigene layer. There is no "transmission mechanism".

A switch positon was set a particlar way, and stays that way till unswitched. That includes staying that way from one generation to another.But it is not PART of the iCT - it is a superimposed damage/disease.
ALL diseases are superimposed, and are not part of every ICT of that name, much less can they apply as needed to all species of t hat ICT. That miasm diseases continue to the next generation, Hahnemann knew, and now modern science also knows - but they are still diseases - damage to a system, not PART of the system - so not part of the Innate Constitutional Type (applicable to ALL species, despite that they have DIFFERENT miasms for the SAME ICT.)

You can not define core or ICT or remedy - for just the "humans with a particular miasm". There would be no logic to that. The ICT is the UN-Changeale aspect of the remedy/ICT/Core - the diseases/damage, cross-generational or otherwise, are not part of it, as they do not occur in ALL memebrs of ALL species that have that ICT. They are not passed down as innate inherited characteristics in all of that ICT's memebrs.

ALL three disease types can be added and can be subtracted from an individual.
ONLY their potential predisposition can be considered an aspect of an ICT. No disease/damage can be part of an ICT. It is a transient (short term or long term but transient) mistunement of the vital force, not part of the makeup of the idividual.
There is no integration of any form of disease into the DNA of any life form.
It is barking up the wrong tree to suggest it.
(We discussed this mistake at length before)
External effects can affect the HEALTH of an individual with a specific ICT (by acute, chronic or miasm disease) but can not change their innate constitutional type - the category of remedy to which they belong - regardless what kind of disease/s they acquire. The disease itself canot be part of that type defintion whatever you call it.
A Phos type of ANY species will remain that way regardless whether they get one or more of the three kinds of diseases - or any other health issues - like poisoning, nutritional deficieinces or excesses, etc.

The health adverse effects are superimposed onto the ICT - they are not part of it - and they last till cured, whether the superimposed issues are injury by poioning, nutrition, acute illness, chronic illness, mental illness or miasmatic epigene switch mechanism damage or physical damage.
Essentially all the forms of health issues are DAMAGE to the ICT, not PART of the ICT.
He was, but nothing he said would make a health issue part of an ICT or core type.
What he recognized is that at least one kind of possible predisposed disease (miasm) could last beyond the lifetime of a specific individual. That does not make it a PART of the individual's category type, just a health damage issue they happen to have a predispositon to get - or not - depending on their life circumstances.
Hahnemann saw there were acutes, chronics and miasms as possible health mistunements. At no time did he suggest that individuals of all species became something else - permanenetly different from any type they had before - in the process.

We need to see diseases (acute, chronic or miasms) in context - as predispositions to which specific ICTs MAY be predisposed till the disease is cured - and that this applies to ALL species as they ALL share the ICT types.
But they do NOT share all disease predispositions, whether acute, chronic or miasm (with some exceptions).
So ICT or Core remedy cannot include diseases - only possible predispositions, by species.
Bird miasms do not happen to affect llamas. Syphilis does not happen to affect many species either. But birds, llamas, people, pigs, lizards and elephants, all have the SAME ICTs as people and get DIFFERENT diseases of all three types.
Miasms are just another form of disease or damage, one that can span more than a generation in any species - as Hahnemann said. It is not more complicated than that.

Namaste,
Irene
--
Irene de Villiers, B.Sc AASCA MCSSA D.I.Hom/D.Vet.Hom.
P.O. Box 4703 Spokane WA 99220.
www.Furryboots.info
(Info on Feline health, genetics, nutrition & homeopathy)
"Man who say it cannot be done should not interrupt one doing it."