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MATERIA MEDICA - Aceticum acidum (4)

Posted: Mon Sep 17, 2001 5:12 am
by Ardavan Shahrdar
Provings and toxicological findings - Aceticum acidum
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From 'A Cyclopaedia of drug Pathogenesy' - Hughes
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ACIDUM ACETICUM.

Acetic acid. Sour principle of vinegar – product of
acetous fermentation of wine, &c., and of pyroligneous
acid – result of destructive distillation of wood.

I. Provings and observations. – I. BERRIDGE records
three cases. And HERING one, in which vinegar
habitually produced flushing of face. In one case this
lasted for hours: in two heat accompanied, in one of
these and one other perspiration. (M. H. R., xv., 297
; A. f. of H. M. M., ix., 245, viii, 222)

2. Threadlike and noticeably retarded pulse, and
decrease of I’35 ‘ F. in temperature, after foot-bath
of strong vinegar. (BOBRIK, in Ziemssen’s Cyclopedia,
xvii, 346.)

3. GMELIN frequently drank, more or less diluted, 3ij
to 3iv of pure pyroligneous acid. Only local effects
were noticed,- burning when acid was taken strong, but
always salivation, eructations, nausea, and tendency
to vomit. Symptoms lasted 2-3 hrs. (Hygea, x, 192.)

II. Poisonings. – I. Woman took over a pint of
vinegar. When seen 3 h. after, was in cold
perspiration, trembling, and much alarmed. Breathing
very laborious and hurried; countenance wild, pupils
dilated; tongue dry and cold; pulse 96 and feeble;
abdomen much distended, with very acute pain in
praecordia, slightest pressure there causing her to
shriek out. Has drunk largely of water. Knew no one,
and recollected nothing since taking vinegar. No pain,
heat, or constriction of fauces.

After 6 h. headache, and after 2 d. slight continued
fever. (DAVID, Boston Med. And Surg. Journ., xxxvii,
134.)

2. A plum and blooming young woman took small glass of
vinegar daily to reduce size. Soon lost flesh and
colour; after a month cough set in, followed by slight
fever, dyspnoea, wasting, night-sweats, anorexia,
finally oedema of extremities, diarrhoea, and death.
No blood or pus expectorated, but much white concocted
phlegm. At autopsy lungs found stuffed with
non-suppurating tubercles (?).

(DESAULT, Diss. De Medecine, 1733, i, 367.)

3. A nursing woman took large quantities of Acet.
Rosarum. Milk became very dilute (sp. Gr. 1002’),
bluish and almost transparent, of sour taste and
smell. Child wasted and died with diarrhoea. Later,
mother also sickened, became very pale, had chronic
metrorrhagia, and dwindled to a skeleton (LANDERER, in
Buchner’s Repertorium, 1847, xlv, 54.)

4. A young German worked for 12 mos. In a vinegar
factory. Appetite soon fell off, and sleep became
broken (taking food promoted it). Later, could not lie
on back, felt as if abdomen would sink in, causing
laboured breathing. Rested better on abdomen. Cold
drinks lay heavy on stomach and caused pressure: cold
victuals also distasteful. From florid became pale and
thin. Vegetables now disagreed, save potatoes; bread
also, and still more butter; had aversion to salted
things. Meat could be taken sparingly; cheese and eggs
agreed. Food tasted right, but went down with
difficulty, causing slow eating. Tongue normal.
Grieved much, and sighed often, which relieved. Going
upstairs was very difficult. Treatment (with Natr.
Mur.) relieved, and he was able to drink cold beer
again; but later symptoms returned, with increased
dyspnoea and ready fatigue, so that he had to leave
factory. (HERING, A. f, of H. M. M., viii, 222.) [The
ascription of the above symptoms to the vinegar may
fairly be questioned. Nevertheless, as this seemed to
be the exciting cause, it has been thought well to put
them on record, as their minute detail would – should
their genuineness be confirmed – be very instructive,-
EDS.]

Sincerely,

Ardavan Shahrdar, MD, DIHom

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