Homeopathic medications as clinical alternatives for symptomatic care of acute otitis media 
and upper respiratory infections in children. Bell IR(1), Boyer NN(2). Glob Adv Health Med. 
2013 Jan;2(1):32-43. doi: 10.7453/gahmj.2013.2.1.007 (1)Department of Family and 
Community Medicine, The University of Arizona College of Medicine and College of Nursing, 
The University of Arizona, Tucson, United States. (2)Private Practice, Rochester, New York, 
United States. The public health and individual risks of inappropriate antibiotic prescribing 
and conventional over-the-counter symptomatic drugs in pediatric treatment of acute otitis 
media (AOM) and upper respiratory infections (URIs) are significant. Clinical research 
suggests that over-the-counter homeopathic medicines offer pragmatic treatment alternatives 
to conventional drugs for symptom relief in children with uncomplicated AOM or URIs. 
Homeopathy is a controversial but demonstrably safe and effective 200-year-old whole 
system of complementary and alternative medicine used worldwide. Numerous clinical 
studies demonstrate that homeopathy accelerates early symptom relief in acute illnesses at 
much lower risk than conventional drug approaches. Evidence-based advantages for 
homeopathy include lower antibiotic fill rates during watchful waiting in otitis media, fewer and 
less serious side effects, absence of drug-drug interactions, and reduced parental sick leave 
from work. Emerging evidence from basic and preclinical science research counter the 
skeptics' claims that homeopathic remedies are biologically inert placebos. Consumers 
already accept and use homeopathic medicines for self care, as evidenced by annual US 
consumer expenditures of $2.9 billion on homeopathic remedies. CONCLUSION: 
Homeopathy appears equivalent to and safer than conventional standard care in comparative 
effectiveness trials, but additional well-designed efficacy trials are indicated. Nonetheless, the 
existing research evidence on safety supports pragmatic use of homeopathy in order to "first 
do no harm" in the early symptom management of otherwise uncomplicated AOM and URIs 
in children.. PMCID: PMC3833578 PMID: 24381823 [PubMed] 
Biphasic dose responses in biology, toxicology and medicine: accounting for their 
generalizability and quantitative features. Calabrese EJ. Environ Pollut. 2013 
Nov;182:452-60. doi: 10.1016/j.envpol.2013.07.046. Epub 2013 Aug 29. Environmental 
Health Sciences Program, School of Public Health, Univ of Massachusetts, Amherst, MA 
01003, USA. edwardc@schoolph.umass.edu   The most common quantitative feature of the 
hormetic-biphasic dose response is its modest stimulatory response which at maximum is 
only 30-60% greater than control values, an observation that is consistently independent of 
biological model, level of organization (viz, cell, organ or individual), endpoint measured, 
chemical/physical agent studied, or mechanism. This quantitative feature suggests an 
underlying "upstream" mechanism common across biological systems, therefore basic and 
general. Hormetic dose response relationships represent an estimate of the peak 
performance of integrative biological processes that are allometrically based. Hormetic 
responses reflect both direct stimulatory or overcompensation responses to damage induced 
by relatively low doses of chemical or physical agents. CONCLUSION: The integration of the 
hormetic dose response within an allometric framework provides, for the first time, an 
explanation for both the generality and the quantitative features of the hormetic dose 
response. Copyright © 2013 Elsevier Ltd. All rights reserved. PMID: 23992683 [PubMed - 
indexed for MEDLINE] 
Antimalarial potential of China 30 and Chelidonium 30 in combination therapy against lethal 
rodent malaria parasite: Plasmodium berghei. J Complement Integr Med. 2013 May 7;10. pii: 
/j/jcim.2013.10.issue-1/jcim-
2012-0016/jcim-2012-0016.xml. doi: 10.1515/jcim-2012-0016. 
Rajan A, Bagai U. Panjab Univ, Chandigarh, India. zoology1808@gmail.com   Homeopathy is 
a therapeutic method based on the application of similia principle, utilizing ultra-low doses of 
medicinal substances made from natural products. The present study has been designed to 
evaluate the efficacy of Cinchona officinalis (Chin.) 30C and Chelidonium majus (Chel.) 30C 
in combination therapy against lethal murine malaria. Five groups having twelve BALB/c mice 
each were administered orally with 0.2 ml/mouse/day of different drugs, and their antimalarial 
potential was evaluated by Peter's 4-day test. The combination of Chin. 30 and Chel. 30 
exhibited complete parasite clearance by the 28th day post-inoculation which was similar to 
the positive control [artesunate (4 mg/kg)+sulphadoxine-primethamine (1.2 mg/kg)] group. 
Both the groups exhibited enhanced mean survival time (MST) 28±0 days,whereas, the mice 
of infected control group survived up to 7.6±0.4 days only. The preventive and curative 
activities of the combination in comparison to the positive controls [pyrimethamine (1.2 
mg/Kg) and chloroquine (20 mg/Kg), respectively] were also evaluated. The combination had 
a significant preventive activity (p  
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