Minutus

A dog got into these muffins made with xylitol and collapsed with seizures and
involuntary urine.
It seems this poisoning has affected the liver.
Xylitol is a sugar alcohol, so should this be treated as an alcohol poisoning?
According to Wikipedia the condition causes severe and immediate hypoglycemia
and can do permanent damage to the liver.
Any experience with remedies or cases?
tanya

from
New findings on the effects
of xylitol ingestion in dogs
Since the onset of signs can be rapid,
emesis should be attempted only if the
animal is asymptomatic. Activated charcoal
is not likely to beneficial. In one in
vitro experiment, activated charcoal was
found to bind a low percentage of xylitol,
and the binding was pHdependent.
26 If a dog ingests between
0.1 and 0.5 g/kg of xylitol, hospitalize
the dog and obtain baseline glucose,
potassium, phosphorus, and total bilirubin
concentrations; liver enzyme activities;
and coagulation measurements.
Monitor blood glucose concentrations
every one to two hours for at least 12
hours, and recheck the other tests every
24 hours for at least 72 hours.
If hypoglycemia develops, administer
a 1- to 2-ml/kg bolus of 25% dextrose
intravenously followed by intravenous
fluids containing 2.5% to 5% dextrose in
order to maintain normal glucose concentrations.
Correct severe hypokalemia
( 0.5 g/kg, the
treatment is the same as outlined
above except I recommend that dextrose
treatment be started immediately,
whether or not hypoglycemia has occurred.
Liver protectants and antioxidants
such as N-acetylcysteine (140 to
280 mg/kg loading dose followed by 70
mg/kg intravenously or orally q.i.d.),
S-adenosylmethionine (Denosyl—
Nutramax; 17 to 20 mg/kg/day orally),
silymarin (Marin [Silybin]—Nutramax;
20 to 50 mg/kg/day orally), or vitamin E
(100 to 400 IU orally b.i.d.) may be useful,
although their efficacy in this toxicosis
has not been established. Plasma
transfusions, blood transfusions, or
both may be needed if a coagulopathy
develops.
PROGNOSIS
The prognosis for uncomplicated hypoglycemia
is good with prompt treatment.
Mild increases in liver enzyme activities
usually resolve within a few days
with supportive care. On the other
hand, if severe elevation of liver enzyme
activities, hyperbilirubinemia, and coagulopathy
develop, the prognosis is
guarded to poor. In addition, hyperphosphatemia
appears to be a poor
prognostic indicator.

http://files.meetup.com/556343/xylitol%20in%20dogs.pdf
Susan

thank you for this clinical information. the dog
is at the vet now so hopefully the blood glucose is
being monitored.
I am looking for homeopathic experience to strenthen/rebuild
the liver. Non-homeopathically, milk thistle, clay, and dandelion for
liver may be helpful.
tanya
From: healthyinfo6@aol.com
Sent: Thursday, February 14, 2013 6:11 AM
To: minutus@yahoogroups.com
Subject: Re: [Minutus] xylitol poisoning in dog

from
New findings on the effects
of xylitol ingestion in dogs
Since the onset of signs can be rapid,
emesis should be attempted only if the
animal is asymptomatic. Activated charcoal
is not likely to beneficial. In one in
vitro experiment, activated charcoal was
found to bind a low percentage of xylitol,
and the binding was p
Hdependent.
26
If a dog ingests between
0.1 and 0.5 g/kg of xylitol, hospitalize
the dog and obtain baseline glucose,
potassium, phosphorus, and total bilirubin
concentrations; liver enzyme activities;
and coagulation measurements.
Monitor blood glucose concentrations
every one to two hours for at least 12
hours, and recheck the other tests every
24 hours for at least 72 hours.
If hypoglycemia develops, administer
a 1- to 2-ml/kg bolus of 25% dextrose
intravenously followed by intravenous
fluids containing 2.5% to 5% dextrose in
order to maintain normal glucose concentrations.
Correct severe hypokalemia
( 0.5 g/kg, the
treatment is the same as outlined
above except I recommend that dextrose
treatment be started immediately,
whether or not hypoglycemia has occurred.
Liver protectants and antioxidants
such as
N-acetylcysteine (140 to
280 mg/kg loading dose followed by 70
mg/kg intravenously or orally q.i.d.),
S
-adenosylmethionine (Denosyl—
Nutramax; 17 to 20 mg/kg/day orally),
silymarin (Marin [Silybin]—Nutramax;
20 to 50 mg/kg/day orally), or vitamin
E
(100 to 400
IU orally b.i.d.) may be useful,
although their efficacy in this toxicosis
has not been established. Plasma
transfusions, blood transfusions, or
both may be needed if a coagulopathy
develops.
P
ROGNOSIS
The prognosis for uncomplicated hypoglycemia
is good with prompt treatment.
Mild increases in liver enzyme activities
usually resolve within a few days
with supportive care. On the other
hand, if severe elevation of liver enzyme
activities, hyperbilirubinemia, and coagulopathy
develop, the prognosis is
guarded to poor. In addition, hyperphosphatemia
appears to be a poor
prognostic indicator.

http://files.meetup.com/556343/xylitol%20in%20dogs.pdf
Susan

All the sugar alcohols *xylitol, sorbitol, etc) are very toxic to cats and dogs and can be lethal very quickly. They cause a rapid release of insulin, so blood sugar can drop drastically fast after ingestion, but the substance is itself also toxic, and the carnivore liver is not designed to metabolize it..

(It's not alcohol poisoning, the "alcohol" nomenclature is due to an OH group but sugar alcohols are not alcohols in the traditional sense.)

Initial reaction needs sugar/dexttrose/glucose fast, as first aid to raise glucose levels and counter the insulin effect, then:
I'd try to detox with 6C or 30C of the sugar alcohol, (increasing in F series if needed) plus a matched remedy for damage done to liver etc.

......Irene
REPLY TO: only
--
Irene de Villiers, B.Sc AASCA MCSSA D.I.Hom/D.Vet.Hom.
P.O. Box 4703 Spokane WA 99220.
www.angelfire.com/fl/furryboots/clickhere.html (Veterinary Homeopath.)
"Man who say it cannot be done should not interrupt one doing it."

NO!!! These are toxic to dogs!!!
Carnivores have a liver NOT designed for herbs or fruit or veg. You'd be adding more toxins.

Use homeopathy.
REPLY TO: only
--
Irene de Villiers, B.Sc AASCA MCSSA D.I.Hom/D.Vet.Hom.
P.O. Box 4703 Spokane WA 99220.
www.angelfire.com/fl/furryboots/clickhere.html (Veterinary Homeopath.)
"Man who say it cannot be done should not interrupt one doing it."