Dear Jean,
There are two provings of Cortisonum, first in 1953 and the second in 1966.
Cortisonum (cortisone acetate, C23H30O6, C21H28O5, cortiso.) (W.L. Templeton 1953, B.K. Sarkar 1966)
For more detail may see extracts.
Regards.
Sarvadaman Oberoi
H 485 FF Ansals Palam Vihar
Gurgaon 122017 Haryana INDIA
Mobile: +919818768349 Tele: +911244076374
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________________________________
From:
minutus@yahoogroups.com [mailto:
minutus@yahoogroups.com] On Behalf Of Irene de Villiers
Sent: Friday, May 04, 2007 12:05 PM
To:
minutus@yahoogroups.com
Subject: Re: [Minutus] cushing syndrome?@Irene
Jean Doherty wrote:
It's not necessary to surmise - there is a proving - it's listed in O A
Julian's repertory.
Euphoria according to?????
(Anything but!)
That's not one I've seen among the couple hundred cushings sufferers on
my Cushings support group list.
The responses to high cortisol are exaggerated but not euphoric -
there's a difference.
There will be tears triggered by far less of a trigger than normal - and
excitement (but not euphoria) triggered also by far less of a trigger
than normal - a doorbell or phone ringing. Either the depression extreme
or the high anxiety excitement extreme can be triggered by relatively
small things - cortisol causes an extreme version of the normal response
to stimuli.
The depression extreme is triggered by the extreme tiredness and
lack of energy - due to the extreme effort needed just to exist at all.
Cortisol uses up a great deal of oxygen, breaks down tissues, leaves
the individual exhausted in a very intense way, every muscle, every
fiber is achingly tired. Just getting up from sitting takes immense
energy and effort for example. Walking across a room can make the person
ready to fall over and collapse from lack of breath and exhaustion.
The excitement extreme feels the way one feels after getting huge
fright (and indeed can trigger heart attacks) but is triggered by
relatively small things - and can escalate very easily if any kind of
stressful situation can not be escaped and avoided immediately and the
use of calming techniques used. This stress situation then can trigger
even more over-reaction - including yelling and crying in frustration
for example.
Neither extreme is any fun!
It's not euphoric!
EXTRACTS
JULIAN O. A., Materia Medica of New Homeopathic Remedies (jl1)
Cortisonum
CORTISONE AND CORTICOIDS
Source
Cortisone , or Kendall's compound "E", is : 17 Hydroxy-11-dehydrocortocosterone, formula C21H28O5; molecular weight = 360.46; melting point = 218-220°.
Cortisone is used in an acetate form, and is prepared today by synthesis.
It is a cortico-suprarenal hormone, belonging to the group of 11 steroids or 11-oxycorticosteroid hormones.
Its fundamental properties are : promotion of the formation of glycogen; diminution of the use of glucides by the tissues, negation of the nitrogen balance, elevation of urinary elimination of uric acid; of creatine (without any change in the level of creatinine in the urine), and of potassium; sodium retention, varying action on the urinary elimination of phosphorous and calcium; degeneration of the lymphoid organs, with lymphocytopenia; increase of globulins in the plasma, and inhibition of conjunctival inflammatory reactions.
In addition, it inhibits the production of A.C. T.H. , and produces atrophy of the suprarenal cortex.
It gives the impression of wellbeing and euphoria, but there is the possibility of maniacal or depressive psychological complaints.
The Corticoids are a group of synthetic bodies whose action is analagous to that of Cortisone, but with greater power at equal weight, and, theoretically, with greater tolerance.
In fact, all corticoids can bring about irregularities, namely : perforation of gastric and duodenal ulcer, gastric and duodenal haemorrhaging, psychological complaints, virilism, acne, osteoporosis, diminution of resistance to infections and to tuberculosis, amenorrhoea, and Cushing's syndrome.
Prednisone and prednisolone (delta-cortisone and delta-hydrocortisone) cause less retention of water and salt, and less potassium reduction in the blood than cortisone, but on the other hand, can be the cause of myopathy.
Amongst the corticoids, the following can be distinguished :
Hydrocortisone , 17 - hydroxycorticosterone.
Delta-cortisone , derived from cortisone by dehydrogenation in position 1 and 2 (cortancyl).
Delta-hydrocortisone (hydrocortancyl).
Dexamethasone , fluorine 9-a-trihydroxy-11 b-17a21 methyl 16 a dioxo 3-20, deltacortisone 1.4 (Decadron).
Delta-methyl-deltacortisone , 16-beta-methyl-delta-1-cortisone (Betalon, Betnesol).
Methyl-beta-delta-hydrocortisone (Medrol).
Triamcinolone , fluorine 9 and hydroxy-16 and delta-1-dehydrocortisone.
Below is given the Hahnemannian proving for cortisone, and a short clinical symptomatology for the corticoids.
Hahnemannian symptomatology of cortisone
The Hahnemannian proving of cortisone was carried out during May and June 1963 (1953?) by W. L. Templeton on eight provers and five controls, using the potencies 6c, 12c and 30c, prepared by A. Nelson and Co. Ltd., from the substance supplied by Organon Ltd.
Generalities
Allergic (psoric ) types , slow and irritable , with a dull psyche .
Suitable especially, but not exclusively, for carbonic types and for Bernard's fat Sulphur types.
Subjects fleshy, with round face, sad, weeping for no reason.
Mind
Psychological
Euphoria, quick changes of mood.
Alternation of excitability with increased activity, and a state of fatigue with weariness.
Heavy , confused , irritable , impatient .
Action calms him.
Memory weak, mental effort arduous, aggravating the general condition.
Difficulty in concentrating.
Thoughts of death, melancholic state.
Nervous
Headache , as from a band around the head .
Sensation of frontal and occipital rending.
Pain stronger around the right eye and forehead.
Pain aggravated by pressure, heat, movement, sun.
Ameliorated in the open air.
Pulsating headache around the right eye, the vertex, and the left side of the occiput.
Vertigo , aggravated in a warm room .
Sleep light, easily disturbed, does not refresh him.
Agitated, cannot sleep, wakes tired.
Endocrine
Face round, puffy, "moon-faced".
Legs swollen , with oedema .
Skin and mucous membranes dry.
Slowness of the body and of the mind, with irritability.
Varying moods.
Morbid hunger.
Polydipsia.
Digestive system
Mouth, tongue, pharynx
Dryness of the mouth , especially in the morning .
Dryness of the throat and pharynx , worse with swallowing, ameliorated by eating warm honey.
Uvula red in colour.
Stomach, intestines, abdomen
Insatiable appetite : has "butterflies" if he does not eat.
Milk and fats provoke nausea .
Amelioration by empty swallowing; aggravated in the morning and by hot drinks.
Diarrhoea on rising in the morning, after breakfast, after a meal.
Constipation and incomplete evacuation of hard stools , in balls .
Respiratory system
Dyspnoea , aggravated in a warm room .
Heaviness behind the sternum, respiration difficult.
Short of breath from nervous irritation, from warming himself, and when in a hot room.
Laryngeal cough, with sneezing in the morning.
Cough aggravated by laughing , by becoming excited, by walking, by physical fatigue, by undressing and by shaving.
Grey, gelatinous sputum.
Sense organs
Nose
Sneezing in the morning, ameliorated by washing.
Ears
Ringing in the ears.
Eyes
Tension behind the eyeballs.
Eyeballs painful, dry, edges of the eyelids agglutinated.
Styes.
Inflammation of the inner canthus.
Foggy vision.
Accommodation difficult.
Urinary and genital organs
Urinary
Urination at night; oliguria.
Frequent, pressing micturition.
Male genital
Diminution of sexual desire.
Female genital
Amenorrhoea in young girls .
Heaviness in the lower abdomen.
Sensation of repletion in the stomach, ameliorated by menstrual flow, and by walking.
Menses copious, blood thick.
Locomotor
Dorsal pain , under the ribs on the left side, spreading to the anterior sacro-iliac region, ameliorated by movement and pressure, aggravated in a sitting position, by bending down, and in the morning.
Acute sacro-iliac pain on the right side, better when lying down or standing, worse when stooping halfway or when seated.
Dorsal pain, as if broken.
Pain between the bones.
Legs restless, not ameliorated by movement in bed.
Pain in the loin, worse when seated or lying down.
Sacro-iliac pain , as if it were about to break.
Drawing pain behind the knees .
Skin
Red streaks on the skin.
Acne of the face, shoulders and back.
Increased growth of hair in the usual places.
Dryness and irritation of the back of the hands.
Face and hands rough, rash in places, worse with the heat.
Round, raised marks, slightly hard, on the hands, ankle, cheek, and left side of the neck.
Itching rash on the legs, feet and hands.
Red rash on the lower part of the sternum, at the nail beds, and on the backs of the fingers.
Dorsum of hands cracked, chapped, with red marks.
Vesicular eruption on the backs of the hands, itching, with round marks, worse with the heat.
Skin of the thorax discoloured.
Skin streaked with weals .
Pathological findings
Retention of chloride and sodium.
Diminution of ascorbic acid.
Loss of potassium, calcium, phosphorus.
Increase of creatinine, cholesterol, uric acid.
Glycosuria.
Increase of the 17 ketosteroids and diminution of the 11 ketosteroids.
Proteinuria.
Tubular casts in the urine.
Increased production of the thrombocytes, erythroid hyperplasia, polymorphism of the leucocytes.
Modalities
Amelioration
From menstrual flow.
From walking, in the evening.
Aggravation
In the morning, from external heat, immobility, scratching, coughing and pressure.
Laterality
Predominantly on the left side.
Dosage
Potencies :
From 5c to 30c.
Principal symptoms
Tendency to obesity, with retention of water.
Unstable mood, alternating between euphoria, melancholy, and excitement.
Loss of willpower.
Right frontal and orbital pain, aggravated by the heat in a room, by pressure, and in the afternoon.
Dryness of the nasal and pharyngeal mucous membranes, with coughing, and dry, sticky eyes.
Sacro-iliac pain, as if the back were about to break.
Skin discoloured, vesicular eruption, dryness and cracking of the skin on the face and hands, with exfoliation of the nail beds.
Related remedies
Sulfur
Impatient, quarrelsome, has grandiose ideas, pain and burning eruptions.
Psorinum
Sad; periodic migraines; anxious; scabby, weeping eruptions; weakness of the back and limbs as if dislocated.
Pulsatilla
Changing, variable, weeps at the slightest trifle, alternation of smiles and tears.
Erratic pains, dry cough, congestion of the veins.
Clinical diagnosis
Generalities
Allergic conditions.
Diabetes.
Cushing's syndrome.
Resistance to infection diminished.
Premature senescence.
Mind
Depressive, melancholic conditions.
Addison's disease.
Ophthalmic migraine.
Sunstroke, heatstroke.
Dysthyroidism, with tendency to hypothyroidism (O. A. Julian).
Digestive system
Hepatic deficiency.
Spasmodic entero-colitis.
Respiratory system
Bronchitis with sputum.
Respiratory allergies.
Sense organs - nose
Allergic rhinitis (hay fever).
Sense organs - eyes
Allergic conjunctivitis.
Styes.
Urinary system
Nephrotic syndrome.
Oedema.
Female genital
Amenorrhoea in young girls.
Pelvic congestion.
Vulvar eczema.
Locomotor
Painful joints.
Osteoporosis.
Leriche's painful post-traumatic osteoporosis.
Skin
Acne; blotchiness.
Eczema with puffiness of the face.
Chapping.
Slow healing of wounds.
Lupus erythematosis.
Psoriasis.
Clinical symptomatology of corticoids
Source
This is a group of synthetic bodies whose action is analogous to that of cortisone (see above).
It can be seen that : Medrone (6 Methyl delta-hydrocortisone) causes principally aggravation of diabetes and provokes gastric and duodenal ulcers; Decadron (dexamethasone) induces necrosis of the bones and osteoporosis; and that Triamcinolone sometimes causes lack of reflex in the tendons, and muscular atrophy of the quadriceps of the lower limbs.
Generalities
General increase in appetite and weight.
Diabetes.
Aggravated infections.
Malignant chickenpox, influenza, shingles.
Acute pancreatitis.
Mind
Psychological
Psychological stimulation.
Nervous
Intra-cranial hypertension.
Headache, vomiting, bradycardia, torpor, impaired vision, vertigo and convulsions; the back of the eye reveals papillary oedema.
Endocrine
Hypercorticism : moon-faced, virilism.
Inhibition of secretion of A.C. T.H.
Goitre.
Digestive system
Gastric ulcer.
Circulatory system
Arterial hypertension.
Purpura.
Ecchymosis.
Sense organs
Eyes :
Cataract.
Locomotor
Osteoporosis.
Osteonecrosis, of the hip in particular.
Muscular atrophy of the quadriceps of the lower limbs.
Biological characteristics
Sodium retention
Loss of potassium.
Dosage
Potencies :
From 5c to 30c.
Principal symptoms
General lack of reaction (diminution of the organic reactional capacity).
Fat and water retention
Intra-cranial hypertension
Rhythmic disorders of several glands : pituitary, adrenal, pancreas.
Acrid dyspepsia, which can lead to gastric ulcers
Cataract.
Oesteoporosis.
Osteonecrosis (especially of the hip).
Related remedies
Cortisone , q.v.
Corticotrophin , q.v.
Clinical diagnosis
See the sections on Cortisone and Corticotrophin.
Also, the principal symptoms, which sum up the clinical indications at the same time.
VARMA P. N. and INDU V., Encyclopaedia of Homoeopathic Pharmacopoeia (vma2)
Cortisonum
(cortisone acetate)
C23H30O6
Mol. Wt.: 402.49
Uses: Anti-inflammatory.
Synonyms: Latin: Cortisoni acetas, cortisonum aceticum; English: Cortisone monoacetate; French: Acetate de cotisone; German: Cortisonacetat
Description: White or practically white, odourless, crystalline powder. It is stable in air. Melts at about 240oC with some decomposition. Insoluble in water, slightly soluble in alcohol. Cortisone acetate contains not less than 97.0 percent and not more than 102.0 percent of C23H30O6, calculated on the dried basis.
History and authority: Stephenson, J.: Provings Homoeopathic Pharmacopoeia of United States.
Preparation: Solution 1/1000 in strong alcohol. Trituration.
a)
Mother Solution 3x Drug strength 1/1000
Cortisone aceticum 1 g
Strong Alcohol in sufficient quantity
To make one litre of the Mother Solution.
b) Potencies: 4x and higher with Dispensing Alcohol.
c) Trituration 1x Drug Strength 1/10
Cortisone aceticum 100 g
Saccharum Lactis 900 g
To make one Kilogramme of the Trituration.
d) Potencies: 2x and higher to be Triturated. 6x may be converted to liquid 8x.
Caution: Lower potencies have side effect and should be used under physician supervision.
Prescribed dose: 3x and higher.
VERMEULEN F., Synoptic Materia Medica 2 (vml3)
Cortisonum
Cortiso.
Signs
Cortisone [from L cortex, corticis, bark].
'Compound E,' a naturally-occurring corticosteroid isolated from the adrenal cortex, or prepared from ox bile, etc, used as an anti-inflammatory agent and in the treatment of Addison's disease.
Endogenously, it is probably a metabolite of hydrocortisone but exhibits no biological activity until converted to hydrocortisone [cortisol]; it acts upon carbohydrate metabolism and influences the nutrition and growth of connective [collagenous] tissues. [Stedman's]
To the class of steroids belong sterols [e.g. , cholesterol], bile acids, adrenal hormones [e.g. , cortisone], sex hormones [such as testosterone and progesterone], vitamin D.
Corticosteroids are currently being used on a large scale in medicine, both internally and externally, in the treatment of allergic reactions, various skin diseases, rheumatoid arthritis and other inflammatory diseases by limiting their spread. The number of side-effects is proportionately large. One of the negative characteristics of these preparations is that they can reactivate latent infections and mask acute disorders, where surgical intervention may be required. They also reduce resistance to infections and can bring about disorders of the water and hormonal systems and the blood pressure, as well as osteoporosis, diabetes, peptic ulcers, hirsutism, acne, amenorrhoea and psychic disorders.
The strong suppressive effect often causes a blockage, especially in the excretory functions from skin and mucous membranes. The result is that the vital force seeks release on a deeper level of sickness.
In patients with a history of corticosteroid use [internal or external!], therefore, Cortisonum in a homoeopathic potency is necessary to regenerate the reactive capacity of the organism and subsequently enable the appropriate constitutional remedy to do its work.
Proved in 1953 by W.L. Templeton on 8 persons. [See: James Stephenson, A Materia Medica and Repertory, and O.A. Julian, Dictionary of Homoeopathic Materia Medica], and by B.K. Sarkar [see: B.K. Sarkar, Up-to-date with nosodes, Calcutta, 1966. ]
Compare
Sulphur. Psorinum. Sepia. Pulsatilla. Ribonucleinicum acidum.
Region
Endocrines. Digestion.
Leading symptoms
M Unstable mood,
alternating between euphoria, melancholy and excitement.
Alternation of excitability with increased activity and a state of fatigue with weariness.
M Irritable and impatient; amel. occupation.
Irritability when travelling too slow.
Delusion bus is going to slow.
G Fat persons with round face [like the full moon], sad mood, causeless weeping. [Julian]
Tendency to obesity with retention of water.
G Slow irritable subjects with a dull mind.
G Increased growth of hair in unusual places.
G Lack of reaction.
Weakness after acute or prostrating diseases.
and Disposition to catch cold. [Voisin]
Physical and mental slowness and irritability.
G agg. Warmth; warm room; sun; heat.
[vertigo; headache; dyspnoea; itching eruption on back of hands; rough skin of face and hands]
G Ravenous hunger.
"Has butterflies if he does not eat." [Murphy]
Faintness when hungry, esp. around noon.
G Milk and fat badly digested [= nausea].
G amel. Menses.
G Dryness of skin and mucous membranes.
Dryness of mouth in morning.
Skin of face and hands rough in patches, agg. heat.
Skin of back of hands red and cracked in patches.
G Fluid retention.
P Dullness and heaviness of head, when stomach is empty, amel. eating.
P Right-sided headaches, above right eye.
agg. Motion; pressure; warm room; sun.
amel. Open air.
Or headache as from a band around the head.
P Allergic rhinitis.
and Allergic conjunctivitis.
P Acne of face, shoulders, back.
P Sensation of fullness in hypogastrium.
amel. Menses; walking.
P Pain in sacroiliac region, agg. right side.
agg. Sitting; rising from sitting.
amel. Lying; standing; pressure; continued motion. [Voisin]
Rubrics
Mind
Cheerfulness ??? vexation [1]. Euphoria ??? sadness [1]. Excitement ??? indecision [1]. Paleness of face and insanity [1; Stram.]. Mannish habits of girls [1]. Witty talk [1].
Head
Pain, headache agg. warmth [1].
Eye
Inflammation of inner canthi [1]. Stitching pain agg. pressure [1]; stitching pain agg. thinking of it [1/1].
Nose
Sneezing in morning amel. washing [1/1].
Mouth
Dryness amel. warm drinks [1/1].
Throat
Dryness agg. empty swallowing [1/1]; amel. warm drinks [1].
Stomach
Nausea after eating fats [1]; after milk [1].
Abdomen
Gurgling as if from water [1].
Kidneys
Pain while lying [1]; when sitting [1].
Female
Menses absent in girls [1]; painful, dysmenorrhoea, amel. walking [1/1].
Cough
Undressing or uncovering body [1].
Back
Pain amel. pressure of cushion [1].
Extremities
Backs of hands cracked [1; Sep.]. Red discolouration of backs of hands, in patches [1/1]. Eruption, eczema on backs of hands [1; Mez.]; agg. warmth [1/1]. Pain at hollow of knee while standing [1]; extending to thigh [1]. Restlessness of legs not amel. by movement in bed [1].
Skin
Eruptions from sun [1]; from warmth [1/1]. Excessive growth of hair [1/1].
Generalities
Hypertension in children [1/1]. Hypothyreoidism [1]. During menses amel. [1]. Obesity [1]. Rest agg. [1]. Walking amel. [1]. Weariness in morning [1]. Wounds slow to heal [1].
Food
Aversion: Bread [1]; fish [1]; meat [1].
Desire: Eggs [1]; pickles [1]; sour [1]; spicy [1].
Worse: Fats and rich food [1]; milk [1].
Better: Warm drinks [1].
Notes
)