Re: Spanish Flu/ re to Swine Flu etc.
Posted: Wed Apr 29, 2009 3:54 am
Hi David,
This issue does not seem to be settled yet - it is only a hypothesis.
I found something about it on pubmed:
****************
1: J Pathol. 2008 Nov;216(3):328-36.
Distinctly different expression of cytokines and chemokines in the
lungs of two H5N1 avian influenza patients.
Deng R, Lu M, Korteweg C, Gao Z, McNutt MA, Ye J, Zhang T, Gu J.
Department of Pathology, School of Basic Medical Sciences, Peking
University, Beijing, People's Republic of China.
The pathogenesis of human H5N1 influenza remains poorly understood and
controversial. 'Cytokine storm' has been hypothesized to be the main
cause of the severity of this disease. However, the significance of
this hypothesis has been called into question by a recent report,
which demonstrates that inhibition of the cytokine response did not
protect against lethal H5N1 influenza infection in mice. Here we
showed discrepant findings in two adult H5N1 autopsies and a fetus
obtained at autopsy which also raise doubt about this hypothesis.
Antigens of 10 cytokines/chemokines which were found to be
significantly elevated in previous H5N1-infected patients and in vitro
experiments, and mRNA of eight of these, were absent from the lungs of
a pregnant woman and her fetus. In contrast, antigens of seven
cytokines/chemokines and mRNA of six of these were found to be
increased in the lungs of a male autopsy. The cells expressing these
cytokines and chemokines were identified as type II pneumocytes,
bronchial epithelial cells, macrophages and vascular endothelial
cells. Levels of cytokines and chemokines in the serum of the male
case were also significantly higher than those of infectious
(infection other than by H5N1) and non-infectious controls. In
comparison with results from our previous study, it appeared that the
male case had increased cytokine/chemokine expression but reduced
viral load, while the pregnant female had diminished
cytokine/chemokine expression but a significantly increased viral load
in the lungs. These disparate findings in these two cases suggest that
'cytokine storm' alone could not be a sufficient explanation for the
severe lung injury of this newly emerging disease. (c) 2008
Pathological Society of Great Britain and Ireland. Published by John
Wiley & Sons, Ltd.
PMID: 18788084 [PubMed - indexed for MEDLINE]
*************
Regards
Luise
--
One thought to all who, free of doubt,
So definitely know what's true:
2 and 2 is 22 -
and 2 times 2 is 2:-)
==========> ICQ yinyang 96391801 <==========
This issue does not seem to be settled yet - it is only a hypothesis.
I found something about it on pubmed:
****************
1: J Pathol. 2008 Nov;216(3):328-36.
Distinctly different expression of cytokines and chemokines in the
lungs of two H5N1 avian influenza patients.
Deng R, Lu M, Korteweg C, Gao Z, McNutt MA, Ye J, Zhang T, Gu J.
Department of Pathology, School of Basic Medical Sciences, Peking
University, Beijing, People's Republic of China.
The pathogenesis of human H5N1 influenza remains poorly understood and
controversial. 'Cytokine storm' has been hypothesized to be the main
cause of the severity of this disease. However, the significance of
this hypothesis has been called into question by a recent report,
which demonstrates that inhibition of the cytokine response did not
protect against lethal H5N1 influenza infection in mice. Here we
showed discrepant findings in two adult H5N1 autopsies and a fetus
obtained at autopsy which also raise doubt about this hypothesis.
Antigens of 10 cytokines/chemokines which were found to be
significantly elevated in previous H5N1-infected patients and in vitro
experiments, and mRNA of eight of these, were absent from the lungs of
a pregnant woman and her fetus. In contrast, antigens of seven
cytokines/chemokines and mRNA of six of these were found to be
increased in the lungs of a male autopsy. The cells expressing these
cytokines and chemokines were identified as type II pneumocytes,
bronchial epithelial cells, macrophages and vascular endothelial
cells. Levels of cytokines and chemokines in the serum of the male
case were also significantly higher than those of infectious
(infection other than by H5N1) and non-infectious controls. In
comparison with results from our previous study, it appeared that the
male case had increased cytokine/chemokine expression but reduced
viral load, while the pregnant female had diminished
cytokine/chemokine expression but a significantly increased viral load
in the lungs. These disparate findings in these two cases suggest that
'cytokine storm' alone could not be a sufficient explanation for the
severe lung injury of this newly emerging disease. (c) 2008
Pathological Society of Great Britain and Ireland. Published by John
Wiley & Sons, Ltd.
PMID: 18788084 [PubMed - indexed for MEDLINE]
*************
Regards
Luise
--
One thought to all who, free of doubt,
So definitely know what's true:
2 and 2 is 22 -
and 2 times 2 is 2:-)
==========> ICQ yinyang 96391801 <==========