Homeopathic medications as clinical alternatives for symptomatic care of acute otitis media
and upper respiratory infections in children. Bell IR(1), Boyer NN(2). Glob Adv Health Med.
2013 Jan;2(1):32-43. doi: 10.7453/gahmj.2013.2.1.007 (1)Department of Family and
Community Medicine, The University of Arizona College of Medicine and College of Nursing,
The University of Arizona, Tucson, United States. (2)Private Practice, Rochester, New York,
United States. The public health and individual risks of inappropriate antibiotic prescribing
and conventional over-the-counter symptomatic drugs in pediatric treatment of acute otitis
media (AOM) and upper respiratory infections (URIs) are significant. Clinical research
suggests that over-the-counter homeopathic medicines offer pragmatic treatment alternatives
to conventional drugs for symptom relief in children with uncomplicated AOM or URIs.
Homeopathy is a controversial but demonstrably safe and effective 200-year-old whole
system of complementary and alternative medicine used worldwide. Numerous clinical
studies demonstrate that homeopathy accelerates early symptom relief in acute illnesses at
much lower risk than conventional drug approaches. Evidence-based advantages for
homeopathy include lower antibiotic fill rates during watchful waiting in otitis media, fewer and
less serious side effects, absence of drug-drug interactions, and reduced parental sick leave
from work. Emerging evidence from basic and preclinical science research counter the
skeptics' claims that homeopathic remedies are biologically inert placebos. Consumers
already accept and use homeopathic medicines for self care, as evidenced by annual US
consumer expenditures of $2.9 billion on homeopathic remedies. CONCLUSION:
Homeopathy appears equivalent to and safer than conventional standard care in comparative
effectiveness trials, but additional well-designed efficacy trials are indicated. Nonetheless, the
existing research evidence on safety supports pragmatic use of homeopathy in order to "first
do no harm" in the early symptom management of otherwise uncomplicated AOM and URIs
in children.. PMCID: PMC3833578 PMID: 24381823 [PubMed]
Biphasic dose responses in biology, toxicology and medicine: accounting for their
generalizability and quantitative features. Calabrese EJ. Environ Pollut. 2013
Nov;182:452-60. doi: 10.1016/j.envpol.2013.07.046. Epub 2013 Aug 29. Environmental
Health Sciences Program, School of Public Health, Univ of Massachusetts, Amherst, MA
01003, USA. edwardc@schoolph.umass.edu The most common quantitative feature of the
hormetic-biphasic dose response is its modest stimulatory response which at maximum is
only 30-60% greater than control values, an observation that is consistently independent of
biological model, level of organization (viz, cell, organ or individual), endpoint measured,
chemical/physical agent studied, or mechanism. This quantitative feature suggests an
underlying "upstream" mechanism common across biological systems, therefore basic and
general. Hormetic dose response relationships represent an estimate of the peak
performance of integrative biological processes that are allometrically based. Hormetic
responses reflect both direct stimulatory or overcompensation responses to damage induced
by relatively low doses of chemical or physical agents. CONCLUSION: The integration of the
hormetic dose response within an allometric framework provides, for the first time, an
explanation for both the generality and the quantitative features of the hormetic dose
response. Copyright © 2013 Elsevier Ltd. All rights reserved. PMID: 23992683 [PubMed -
indexed for MEDLINE]
Antimalarial potential of China 30 and Chelidonium 30 in combination therapy against lethal
rodent malaria parasite: Plasmodium berghei. J Complement Integr Med. 2013 May 7;10. pii:
/j/jcim.2013.10.issue-1/jcim-
2012-0016/jcim-2012-0016.xml. doi: 10.1515/jcim-2012-0016.
Rajan A, Bagai U. Panjab Univ, Chandigarh, India. zoology1808@gmail.com Homeopathy is
a therapeutic method based on the application of similia principle, utilizing ultra-low doses of
medicinal substances made from natural products. The present study has been designed to
evaluate the efficacy of Cinchona officinalis (Chin.) 30C and Chelidonium majus (Chel.) 30C
in combination therapy against lethal murine malaria. Five groups having twelve BALB/c mice
each were administered orally with 0.2 ml/mouse/day of different drugs, and their antimalarial
potential was evaluated by Peter's 4-day test. The combination of Chin. 30 and Chel. 30
exhibited complete parasite clearance by the 28th day post-inoculation which was similar to
the positive control [artesunate (4 mg/kg)+sulphadoxine-primethamine (1.2 mg/kg)] group.
Both the groups exhibited enhanced mean survival time (MST) 28±0 days,whereas, the mice
of infected control group survived up to 7.6±0.4 days only. The preventive and curative
activities of the combination in comparison to the positive controls [pyrimethamine (1.2
mg/Kg) and chloroquine (20 mg/Kg), respectively] were also evaluated. The combination had
a significant preventive activity (p
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